The Japanese Ministry of Health, Labour, and Welfare (MHLW), Ministry of Economy, Trade, and Industry (METI), and Ministry of the Environment (MoE) held consultations on 18 February 2023, regarding a ban on the production and import of PFHxS and its salts, as well as the import of some product types containing them, through a partial revision to the Chemical Substance Control Law's (CSCL) Enforcement Ordinance. The action aims to bring the nation into compliance with a global PFHxS ban adopted by the Stockholm Convention on POPs last year.

According to the announcement, comments were given a deadline of 19 March 2023.

The three ministries designated the substance as a Class I specified chemical. According to the CSCL, Class I specified chemicals are those that Japan has determined to be persistent, extremely bioaccumulative, or which have a risk of long-term toxicity to humans.